Supramolecular Hydrogels for Protein Delivery in Tissue Engineering.

ABSTRACT: Therapeutic proteins, such as growth factors (GFs), have been used in tissue engineering (TE) approaches for their ability to provide signals to cells and orchestrate the formation of functional tissue. However, to be effective and minimize off-target effects, GFs should be delivered at the target site with temporal control. In addition, protein drugs are typically sensitive water soluble macromolecules with delicate structure. As such, hydrogels, containing large amounts of water, provide a compatible environment for the direct incorporation of proteins within the hydrogel network, while their release rate can be tuned by engineering the network chemistry and density. Being formed by transient crosslinks, afforded by non-covalent interactions, supramolecular hydrogels offer important adva

SUBMITTER: Lyu Y 

PROVIDER: S-EPMC7914635 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature