A Mathematical Radiobiological Model (MRM) to Predict Complex DNA Damage and Cell Survival for Ionizing Particle Radiations of Varying Quality.

ABSTRACT: Predicting radiobiological effects is important in different areas of basic or clinical applications using ionizing radiation (IR); for example, towards optimizing radiation protection or radiation therapy protocols. In this case, we utilized as a basis the 'MultiScale Approach (MSA)' model and developed an integrated mathematical radiobiological model (MRM) with several modifications and improvements. Based on this new adaptation of the MSA model, we have predicted cell-specific levels of initial complex DNA damage and cell survival for irradiation with ¹¹Β, ¹²C, ¹⁴Ν, ¹⁶Ο, ²⁰Νe, ⁴⁰Αr, ²⁸Si and ⁵⁶Fe ions by using only three input parameters (particle's LET and two cell-specific parameters: the cross sec

SUBMITTER: Kalospyros SA 

PROVIDER: S-EPMC7914858 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature