Subcellular Localization of uc.8+ as a Prognostic Biomarker in Bladder Cancer Tissue.

ABSTRACT: Non-coding RNA transcripts originating from Ultraconserved Regions (UCRs) have tissue-specific expression and play relevant roles in the pathophysiology of multiple cancer types. Among them, we recently identified and characterized the ultra-conserved-transcript-8+ (uc.8+), whose levels correlate with grading and staging of bladder cancer. Here, to validate uc.8+ as a potential biomarker in bladder cancer, we assessed its expression and subcellular localization by using tissue microarray on 73 human bladder cancer specimens. We quantified uc.8+ by in-situ hybridization and correlated its expression levels with clinical characteristics and patient survival. The analysis of subcellular localization indicated the simultaneous presence of uc.8+ in the cytoplasm and nucleus of cells from the Lo

SUBMITTER: Terreri S 

PROVIDER: S-EPMC7914980 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature