Mechanisms of Resistance to Conventional Therapies for Osteosarcoma.

ABSTRACT: Osteosarcoma (OS) is the most common primary bone tumor, mainly occurring in children and adolescents. Current standard therapy includes tumor resection associated with multidrug chemotherapy. However, patient survival has not evolved for the past decades. Since the 1970s, the 5-year survival rate is around 75% for patients with localized OS but dramatically drops to 20% for bad responders to chemotherapy or patients with metastases. Resistance is one of the biological processes at the origin of therapeutic failure. Therefore, it is necessary to better understand and decipher molecular mechanisms of resistance to conventional chemotherapy in order to develop new strategies and to adapt treatments for patients, thus improving the survival rate. This review will describe most of the molecula

SUBMITTER: Marchandet L 

PROVIDER: S-EPMC7915189 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature