Variation of DNA Methylation in Newborns Associated with Exhaled Carbon Monoxide during Pregnancy.

ABSTRACT: Fetal exposure to tobacco smoke is an adverse risk factor for newborns. A plausible mechanism of how this exposure may negatively impact long term health is differential methylation of deoxyribonucleic acid (DNAm) and its relation to birth weight. We examined whether self-reported gestational smoking status and maternal exhaled carbon monoxide (eCO) during early pregnancy were associated with methylation of cytosine by guanines (CpG) sites that themselves predicted birth weight. We focused first on CpGs associated with maternal smoking, and secondly, among these, on CpGs related to birth weight found in another cohort. Then in 94 newborns from the Breathing for Life Trial (BLT) DNAm levels in cord blood were determined using Infinium Methylation EPIC BeadChip measuring >850K CpGs. We regre

SUBMITTER: De Queiroz Andrade E 

PROVIDER: S-EPMC7915220 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature