A Miniaturized Platform for Multiplexed Drug Response Imaging in Live Tumors.

ABSTRACT: By observing the activity of anti-cancer agents directly in tumors, there is potential to greatly expand our understanding of drug response and develop more personalized cancer treatments. Implantable microdevices (IMD) have been recently developed to deliver microdoses of chemotherapeutic agents locally into confined regions of live tumors; the tissue can be subsequently removed and analyzed to evaluate drug response. This method has the potential to rapidly screen multiple drugs, but requires surgical tissue removal and only evaluates drug response at a single timepoint when the tissue is excised. Here, we describe a "lab-in-a-tumor" implantable microdevice (LIT-IMD) platform to image cell-death drug response within a live tumor, without requiring surgical resection or tissue processing.

SUBMITTER: Bhagavatula S 

PROVIDER: S-EPMC7915324 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature