Behavioral Characterizing of CD24 Knockout Mouse-Cognitive and Emotional Alternations.

ABSTRACT: CD24 is a small, glycophosphatidylinositol-anchored cell surface protein, mostly investigated with respect to cancer, inflammation, and autoimmune diseases. CD24 knockdown or inhibition has been used to test various biochemical mechanisms and neurological conditions; however, the association between CD24 and behavioral phenotypes has not yet been examined. This study aims to characterize cognitive and emotional functions of CD24 knockout mice (CD24^-/-) compared with CD24 wild-type mice at three time-points: adolescence, young adulthood, and adulthood. Our results show that CD24^-/- mice exhibited better cognitive performance and less anxiety-like behavior compared with WT mice, with no effect on depression-like behavior. This phenotype was constant from childhood (2 mo

SUBMITTER: Nitzan K 

PROVIDER: S-EPMC7915412 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature