The Identification of Small Molecule Inhibitors That Reduce Invasion and Metastasis of Aggressive Cancers.

ABSTRACT: Transformed epithelial cells can activate programs of epithelial plasticity and switch from a sessile, epithelial phenotype to a motile, mesenchymal phenotype. This process is linked to the acquisition of an invasive phenotype and the formation of distant metastases. The development of compounds that block the acquisition of an invasive phenotype or revert the invasive mesenchymal phenotype into a more differentiated epithelial phenotype represent a promising anticancer strategy. In a high-throughput assay based on E-cadherin (re)induction and the inhibition of tumor cell invasion, 44,475 low molecular weight (LMW) compounds were screened. The screening resulted in the identification of candidate compounds from the PROAM02 class. Selected LMW compounds activated E-cadherin promoter activit

SUBMITTER: van de Merbel AF 

PROVIDER: S-EPMC7915539 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature