Characterization of Hepatitis B Virus Integrations Identified in Hepatocellular Carcinoma Genomes.

ABSTRACT: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. Almost half of HCC cases are associated with hepatitis B virus (HBV) infections, which often lead to HBV sequence integrations in the human genome. Accurate identification of HBV integration sites at a single nucleotide resolution is critical for developing a better understanding of the cancer genome landscape and of the disease itself. Here, we performed further analyses and characterization of HBV integrations identified by our recently reported VIcaller platform in recurrent or known HCC genes (such as TERT, MLL4, and CCNE1) as well as non-recurrent cancer-related genes (such as CSMD2, NKD2, and RHOU). Our pathway enrichment analysis revealed multiple pathways involvi

SUBMITTER: Mathkar PP 

PROVIDER: S-EPMC7915589 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature