Revisiting Steroidogenic Pathways in the Human Placenta and Primary Human Trophoblast Cells.

ABSTRACT: Steroid hormones play a crucial role in supporting a successful pregnancy and ensuring proper fetal development. The placenta is one of the principal tissues in steroid production and metabolism, expressing a vast range of steroidogenic enzymes. Nevertheless, a comprehensive characterization of steroidogenic pathways in the human placenta and potential developmental changes occurring during gestation are poorly understood. Furthermore, the specific contribution of trophoblast cells in steroid release is largely unknown. Thus, this study aimed to (i) identify gestational age-dependent changes in the gene expression of key steroidogenic enzymes and (ii) explore the role of trophoblast cells in steroid biosynthesis and metabolism. Quantitative and Droplet Digital PCR analysis of 12 selected e

SUBMITTER: Karahoda R 

PROVIDER: S-EPMC7915605 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature