Brain Structural Covariance Networks in Behavioral Variant of Frontotemporal Dementia.

ABSTRACT: Recent research on behavioral variant frontotemporal dementia (bvFTD) has shown that personality changes and executive dysfunctions are accompanied by a disease-specific anatomical pattern of cortical and subcortical atrophy. We investigated the structural topological network changes in patients with bvFTD in comparison to healthy controls. In particular, 25 bvFTD patients and 20 healthy controls underwent structural 3T MRI. Next, bilaterally averaged values of 34 cortical surface areas, 34 cortical thickness values, and six subcortical volumes were used to capture single-subject anatomical connectivity and investigate network organization using a graph theory approach. Relative to controls, bvFTD patients showed altered small-world properties and decreased global efficiency, suggesting a

SUBMITTER: Nigro S 

PROVIDER: S-EPMC7915789 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature