Focal Adhesion Kinase Fine Tunes Multifaced Signals toward Breast Cancer Progression.

ABSTRACT: Breast cancer represents the most common diagnosed malignancy and the main leading cause of tumor-related death among women worldwide. Therefore, several efforts have been made in order to identify valuable molecular biomarkers for the prognosis and prediction of therapeutic responses in breast tumor patients. In this context, emerging discoveries have indicated that focal adhesion kinase (FAK), a non-receptor tyrosine kinase, might represent a promising target involved in breast tumorigenesis. Of note, high FAK expression and activity have been tightly correlated with a poor clinical outcome and metastatic features in several tumors, including breast cancer. Recently, a role for the integrin-FAK signaling in mechanotransduction has been suggested and the function of FAK within the breast

SUBMITTER: Rigiracciolo DC 

PROVIDER: S-EPMC7915897 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature