Cancer-Associated Fibroblast Subgroups Showing Differential Promoting Effect on HNSCC Progression.

ABSTRACT: Background: The critical effect of the tumor microenvironment on cancer progression is well recognized. Recent research suggests that the cancer-promoting properties of the tumor stroma may be attributed to fibroblasts. However, the effect of cancer-associated fibroblast (CAF) on the progression of head and neck squamous cell carcinoma (HNSCC) is not well known. Methods: From the immunohistochemical analysis of head and neck squamous cell carcinoma (HNSCC) tissues, we divided CAF into two groups depending on the presence or absence of a well-demarcated boundary between epithelial cancer cells and the surrounding extracellular matrix (ECM). Primary culture of CAF was performed, followed by co-transplantation with HNSCC cells into mice oral mucosa, and the tumorigenesis was com

SUBMITTER: Kang SH 

PROVIDER: S-EPMC7915931 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature