HIV-1 Tat Activates Akt/mTORC1 Pathway and AICDA Expression by Downregulating Its Transcriptional Inhibitors in B Cells.
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ABSTRACT:
SUBMITTER: Akbay B
PROVIDER: S-EPMC7915967 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
HIV-1 Tat Activates Akt/mTORC1 Pathway and AICDA Expression by Downregulating Its Transcriptional Inhibitors in B Cells.
Akbay Burkitkan B Germini Diego D Bissenbaev Amangeldy K AK Musinova Yana R YR Sheval Evgeny V EV Vassetzky Yegor Y Dokudovskaya Svetlana S
International journal of molecular sciences 20210204 4
HIV-1 infects T cells, but the most frequent AIDS-related lymphomas are of B-cell origin. Molecular mechanisms of HIV-1-induced oncogenic transformation of B cells remain largely unknown. HIV-1 Tat protein may participate in this process by penetrating and regulating gene expression in B cells. Both immune and cancer cells can reprogram communications between extracellular signals and intracellular signaling pathways via the Akt/mTORC1 pathway, which plays a key role in the cellular response to ...[more]
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