Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study.

ABSTRACT: Scope: To identify a metabolomic profile related to postprandial satiety sensations involved in appetite control would help for a better understanding of the regulation of food intake. Methods and Results: A cross-sectional analysis of plasma metabolites was conducted over 151 overweight/obese adults from the "Satiety Innovation"-SATIN study, a randomized clinical trial of a 12-week weight-loss maintenance period. Postprandial satiety sensations (3 h-iAUC) were assessed by visual analogue scale (VAS) at the beginning and at the end of the study. Fasting plasma metabolites were profiled using a targeted multiplatform metabolomics approach before each appetite test meal. Associations between 124 metabolites and iAUC-satiety were assessed using elastic net linear regression analyses. T

SUBMITTER: Camacho-Barcia L 

PROVIDER: S-EPMC7916078 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature