Epigenetic Alterations in Triple-Negative Breast Cancer-The Critical Role of Extracellular Matrix.

ABSTRACT: Triple-negative breast cancer (TNBC) is an aggressive subgroup of breast cancer characterized by genomic complexity and therapeutic options limited to only standard chemotherapy. Although it has been suggested that stratifying TNBC patients by pathway-specific molecular alterations may predict benefit from specific therapeutic agents, application in routine clinical practice has not yet been established. There is a growing body of the literature supporting that epigenetic modifications comprised by DNA methylation, chromatin remodeling and non-coding RNAs play a fundamental role in TNBC pathogenesis. Extracellular matrix (ECM) is a highly dynamic 3D network of macromolecules with structural and cellular regulatory roles. Alterations in the expression of ECM components result in uncontrolle

SUBMITTER: Zolota V 

PROVIDER: S-EPMC7916242 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature