Clinical and metabolomic predictors of regression to normoglycemia in a population at intermediate cardiometabolic risk.

ABSTRACT:

Background

Impaired fasting glucose (IFG) is a prevalent and potentially reversible intermediate stage leading to type 2 diabetes that increases risk for cardiometabolic complications. The identification of clinical and molecular factors associated with the reversal, or regression, from IFG to a normoglycemia state would enable more efficient cardiovascular risk reduction strategies. The aim of this study was to identify clinical and biological predictors of regression to normoglycemia in a non-European population characterized by high rates of type 2 diabetes.

Methods

We conducted a prospective, population-based study among 9637 Mexican individuals using clinical features and plasma metabolites. Among them, 491 subjects were classified as IFG, defined as fasting glucose bet

SUBMITTER: Sevilla-Gonzalez MDR 

PROVIDER: S-EPMC7916268 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature