The small molecule ZY-214-4 may reduce the virulence of Staphylococcus aureus by inhibiting pigment production.

ABSTRACT:

Background

In recent years, clinical Staphylococcus aureus isolates have become highly resistant to antibiotics, which has raised concerns about the ability to control infections by these organisms. The aim of this study was to clarify the effect of a new small molecule, ZY-214-4 (C₁₉H₁₁BrNO₄), on S. aureus pigment production.

Results

At the concentration of 4 μg/mL, ZY-214-4 exerted a significant inhibitory effect on S. aureus pigment synthesis, without affecting its growth or inducing a toxic effect on the silkworm. An oxidant sensitivity test and a whole-blood killing test indicated that the S. aureus survival rate decreased significantly with ZY-214-4 treatment. Additionally, ZY-214-4 administration significantly reduced the expression of

SUBMITTER: Yu J 

PROVIDER: S-EPMC7916275 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature