The role of the gut microbiota on the metabolic status of obese children.

ABSTRACT:

Background

The term "metabolically healthy obese (MHO)" denotes a hale and salutary status, yet this connotation has not been validated in children, and may, in fact, be a misnomer. As pertains to obesity, the gut microbiota has garnered attention as conceivably a nosogenic or, on the other hand, protective participator.

Objective

This study explored the characteristics of the fecal microbiota of obese Chinese children and adolescents of disparate metabolic statuses, and the associations between their gut microbiota and circulating proinflammatory factors, such as IL-6, TNF-α, lipopolysaccharide-binding protein (LBP), and a cytokine up-regulator and mediator, leptin.

Results

Based on weight and metabolic status, the 86 Chinese children (ages 5-15 years) were divided i

SUBMITTER: Yuan X 

PROVIDER: S-EPMC7916301 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature