FK866 Protects Human Dental Pulp Cells against Oxidative Stress-Induced Cellular Senescence.

ABSTRACT: FK866 possesses various functional properties, such as anti-angiogenic, anti-cancer, and anti-inflammatory activities. We previously demonstrated that premature senescence of human dental pulp cells (hDPCs) was induced by hydrogen peroxide (H₂O₂). The present study aimed to investigate whether H₂O₂-induced premature senescence of hDPCs is affected by treatment with FK866. We found that FK866 markedly inhibited the senescent characteristics of hDPCs after exposure to H₂O₂, as revealed by an increase in the number of senescence-associated β-galactosidase (SA-β-gal)-positive hDPCs and the upregulation of the p21 and p53 proteins, which acts as molecular indicators of cellular senescence. Moreover, the stimulatory effects of H

SUBMITTER: Ok CY 

PROVIDER: S-EPMC7916510 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature