The Distinctive Serum Metabolomes of Gastric, Esophageal and Colorectal Cancers.

ABSTRACT: Three of the most lethal cancers in the world are the gastrointestinal cancers-gastric (GC), esophageal (EC) and colorectal cancer (CRC)-which are ranked as third, sixth and fourth in cancer deaths globally. Early detection of these cancers is difficult, and a quest is currently on to find non-invasive screening tests to detect these cancers. The reprogramming of energy metabolism is a hallmark of cancer, notably, an increased dependence on aerobic glycolysis which is often referred to as the Warburg effect. This metabolic change results in a unique metabolic profile that distinguishes cancer cells from normal cells. Serum metabolomics analyses allow one to measure the end products of both host and microbiota metabolism present at the time of sample collection. It is a non-invasive procedu

SUBMITTER: Ren Z 

PROVIDER: S-EPMC7916516 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature