Phenotype characteristics of gastric epithelial mucus in patients with different gastric diseases: from superficial gastritis to gastric cancer.

ABSTRACT:

Background

Gastric gland mucin is important for maintaining the basic function of the gastric mucosa, protecting it from foreign substances and reducing the occurrence of gastric diseases. Exploring the phenotype of gastric gland mucus changes during the progression of gastric disease is of great clinical significance.

Methods

A total of 483 patients with different gastric diseases were collected in this study, including 82 superficial gastritis (SG), 81 atrophic gastritis (AG), 168 dysplasia (GD), and 152 gastric cancer (GC). Mucin staining was performed using HID-ABpH2.5-PAS method and was further grouped according to the mucin coloration.

Results

The phenotypic characteristics of mucin during disease progression were divided into neutral, acidic, and mucus-free typ

SUBMITTER: Dong N 

PROVIDER: S-EPMC7916529 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature