Chemical Constituent Profiling of Phyllostachys heterocycla var. Pubescens with Selective Cytotoxic Polar Fraction through EGFR Inhibition in HepG2 Cells.

ABSTRACT: Different extracts of the Bamboo shoot skin Phyllostachys heterocycla var. pubescens were screened against panel of cancer cell lines and normal one. The cell viability results exhibited that the ethyl acetate extract showed the least vitality percentage of 2.14% of HepG2 cells. Accordingly, it was subjected to chromatographic separation, which resulted in the isolation of a new natural product; 7-hydroxy, 5-methoxy, methyl cinnamate (1), together with four known compounds. The structures of the pure isolated compounds were deduced based on different spectroscopic data. The new compound (1) was screened against the HepG2 and MCF-7 cells and showed IC₅₀ values of 7.43 and 10.65 µM, respectively. It induced apoptotic cell death in HepG2 with total apoptotic ce

SUBMITTER: Abdelhameed RFA 

PROVIDER: S-EPMC7916669 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature