From Stripes to a Beating Heart: Early Cardiac Development in Zebrafish.

ABSTRACT: The heart is the first functional organ to form during vertebrate development. Congenital heart defects are the most common type of human birth defect, many originating as anomalies in early heart development. The zebrafish model provides an accessible vertebrate system to study early heart morphogenesis and to gain new insights into the mechanisms of congenital disease. Although composed of only two chambers compared with the four-chambered mammalian heart, the zebrafish heart integrates the core processes and cellular lineages central to cardiac development across vertebrates. The rapid, translucent development of zebrafish is amenable to in vivo imaging and genetic lineage tracing techniques, providing versatile tools to study heart field migration and myocardial progenitor addition and

SUBMITTER: Kemmler CL 

PROVIDER: S-EPMC7916704 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature