Vaccine candidate designed against carcinoembryonic antigen-related cell adhesion molecules using immunoinformatics tools.

ABSTRACT: Carcinoembryonic antigen-related cell adhesion (CEACAM) molecules belong to a family of membrane glycoproteins that mediate intercellular interactions influencing cellular growth, immune cell activation, apoptosis, and tumor suppression. Several family members (CEACAM1, CEACAM5, and CEACAM6) are highly expressed in cancers, and they share a conserved N-terminal domain that serves as an attractive target for cancer immunotherapy. A multi-epitope vaccine candidate against this conserved domain has been developed using immunoinformatics tools. Specifically, several epitopes predicted to interact with MHC class I and II molecules were linked together with appropriate linkers. The tertiary structure of the vaccine is generated by homology and ab initio modeling. Molecular docking of epit

SUBMITTER: Gupta A 

PROVIDER: S-EPMC7916821 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature