Descriptive and Functional Genomics in Acute Myeloid Leukemia (AML): Paving the Road for a Cure.

ABSTRACT: Over the past decades, genetic advances have allowed a more precise molecular characterization of AML with the identification of novel oncogenes and tumor suppressors as part of a comprehensive AML molecular landscape. Recent advances in genetic sequencing tools also enabled a better understanding of AML leukemogenesis from the preleukemic state to posttherapy relapse. These advances resulted in direct clinical implications with the definition of molecular prognosis classifications, the development of treatment recommendations based on minimal residual disease (MRD) measurement and the discovery of novel targeted therapies, ultimately improving AML patients' overall survival. The more recent development of functional genomic studies, pushed by novel molecular biology technologies (short ha

SUBMITTER: Pasquer H 

PROVIDER: S-EPMC7916915 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature