Impact of [¹⁸F]FDG-PET and [¹⁸F]FLT-PET-Parameters in Patients with Suspected Relapse of Irradiated Lung Cancer.

ABSTRACT: Radiation-induced changes may cause a non-malignant high 2-deoxy-2-[¹⁸F]fluoro-d-glucose (FDG)-uptake. The 3'-deoxy-3'-[¹⁸F]fluorothymidine (FLT)-PET/CT performs better in the differential diagnosis of inflammatory changes and lung lesions with a higher specificity than FDG-PET/CT. We investigated the association between post-radiotherapy FDG-PET-parameters, FLT-PET-parameters, and outcome. Sixty-one patients suspected for having a relapse after definitive radiotherapy for lung cancer were included. All the patients had FDG-PET/CT and FLT-PET/CT. FDG-PET- and FLT-PET-parameters were collected from within the irradiated high-dose volume (HDV) and from recurrent pulmonary lesions. For associations between PET-parameters and relapse status, respectively, the overall surv

SUBMITTER: Christensen TN 

PROVIDER: S-EPMC7916960 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature