Optimizing antiviral treatment for seasonal influenza in the USA: a mathematical modeling analysis.

ABSTRACT:

Background

Seasonal influenza remains a major cause of morbidity and mortality in the USA. Despite the US Centers for Disease Control and Prevention recommendation promoting the early antiviral treatment of high-risk patients, treatment coverage remains low.

Methods

To evaluate the population-level impact of increasing antiviral treatment timeliness and coverage among high-risk patients in the USA, we developed an influenza transmission model that incorporates data on infectious viral load, social contact, and healthcare-seeking behavior. We modeled the reduction in transmissibility in treated individuals based on their reduced daily viral load. The reduction in hospitalizations following treatment was based on estimates from clinical trials. We calibrated the model to weekl

SUBMITTER: Yechezkel M 

PROVIDER: S-EPMC7917004 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature