Gene-Microbiome Co-expression Networks in Colon Cancer.

ABSTRACT: It is known that cancer onset and development arise from complex, multi-factorial phenomena spanning from the molecular, functional, micro-environmental, and cellular up to the tissular and organismal levels. Important advances have been made in the systematic analysis of the molecular (mostly genomic and transcriptomic) within large studies of high throughput data such as The Cancer Genome Atlas collaboration. However, the role of the microbiome in the induction of biological changes needed to reach these pathological states remains to be explored, largely because of scarce experimental data. In recent work a non-standard bioinformatics strategy was used to indirectly quantify microbial abundance from TCGA RNA-seq data, allowing the evaluation of the microbiome in well-characterized cance

SUBMITTER: Uriarte-Navarrete I 

PROVIDER: S-EPMC7917223 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature