Antigenic Essence: Upgrade of Cellular Cancer Vaccines.

ABSTRACT: The development of anticancer immunotherapy is characterized by several approaches, the most recognized of which include cellular vaccines, tumor-associated antigens (TAAs), neoantigens, and chimeric antigen receptor T cells (CAR-T). This paper presents antigenic essence technology as an effective means for the production of new antigen compositions for anticancer vaccination. This technology is developed via proteomics, cell culture technology, and immunological assays. In terms of vaccine development, it does not fit into any of the above-noted approaches and can be considered a new direction. Here we review the development of this technology, its main characteristics, comparison with existing approaches, and the features that distinguish it as a novel approach to anticancer vaccination.

SUBMITTER: Lokhov PG 

PROVIDER: S-EPMC7917603 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature