Serum Acylcarnitines Associated with High Short-Term Mortality in Patients with Alcoholic Hepatitis.

ABSTRACT: Alcohol-related liver disease is one of the most prevalent liver diseases in the United States. Early stages of alcohol-related liver disease are characterized by accumulation of triglycerides in hepatocytes. Alcoholic hepatitis is a severe form of alcohol-related liver disease associated with significant morbidity and mortality. We sought to identify patients who are at greatest risk of death using serum lipids. First, we performed lipidomics analysis on serum samples collected from 118 patients with alcoholic hepatitis to identify lipid markers that are associated with high risk of death. Next, we performed gene set enrichment analysis on liver transcriptomics data to identify dysregulated lipid metabolism in patients who received liver transplantation. Finally, we built a random forest

SUBMITTER: Gao B 

PROVIDER: S-EPMC7917657 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature