Regulatory Control of Rishirilide(s) Biosynthesis in Streptomyces bottropensis.

ABSTRACT: Streptomycetes are well-known producers of numerous bioactive secondary metabolites widely used in medicine, agriculture, and veterinary. Usually, their genomes encode 20-30 clusters for the biosynthesis of natural products. Generally, the onset and production of these compounds are tightly coordinated at multiple regulatory levels, including cluster-situated transcriptional factors. Rishirilides are biologically active type II polyketides produced by Streptomyces bottropensis. The complex regulation of rishirilides biosynthesis includes the interplay of four regulatory proteins encoded by the rsl-gene cluster: three SARP family regulators (RslR1-R3) and one MarR-type transcriptional factor (RslR4). In this work, employing gene deletion and overexpression experiments we revea

SUBMITTER: Tsypik O 

PROVIDER: S-EPMC7917814 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature