Proteomic Adaptation of Clostridioides difficile to Treatment with the Antimicrobial Peptide Nisin.

ABSTRACT: Clostridioides difficile is the leading cause of antibiotic-associated diarrhea but can also result in more serious, life-threatening conditions. The incidence of C. difficile infections in hospitals is increasing, both in frequency and severity, and antibiotic-resistant C. difficile strains are advancing. Against this background antimicrobial peptides (AMPs) are an interesting alternative to classic antibiotics. Information on the effects of AMPs on C. difficile will not only enhance the knowledge for possible biomedical application but may also provide insights into mechanisms of C. difficile to adapt or counteract AMPs. This study applies state-of-the-art mass spectrometry methods to quantitatively investigate the proteomic response of C. difficile<

SUBMITTER: Maaß S 

PROVIDER: S-EPMC7918085 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature