Direct Visualization of Fungal Burden in Filamentous Fungus-Infected Silkworms.

ABSTRACT: Invasive fungal infections (IFIs) are difficult to diagnose and to treat and, despite several available antifungal drugs, cause high mortality rates. In the past decades, the incidence of IFIs has continuously increased. More recently, SARS-CoV-2-associated lethal IFIs have been reported worldwide in critically ill patients. Combating IFIs requires a more profound understanding of fungal pathogenicity to facilitate the development of novel antifungal strategies. Animal models are indispensable for studying fungal infections and to develop new antifungals. However, using mammalian animal models faces various hurdles including ethical issues and high costs, which makes large-scale infection experiments extremely challenging. To overcome these limitations, we optimized an invertebrate model a

SUBMITTER: Yu Y 

PROVIDER: S-EPMC7918154 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature