Microneme Protein 6 Is Involved in Invasion and Egress by Neospora caninum.

ABSTRACT: Neospora caninum, is the etiological agent of neosporosis, an infection that causes abortions in cattle and nervous system dysfunction in dogs. Invasion and egress are the key steps of the pathogenesis of N. caninum infection. Microneme proteins (MICs) play important roles in the recognition, adhesion, and invasion of host cells in other apicomplexan parasites. However, some MICs and their functions in N. caninum infection have rarely been reported. The homologous recombination strategy was used to investigate the function of MIC6 in N. caninum infection. ΔNcMIC6 showed a smaller plaque size and weakened capacities of invasion and egress than Nc1. Transcription levels of the egress-related genes CDPK1, PLP1, and AMA1 of ΔNcMIC6 were downregulated. Due to the lack of NcMIC6, virulence of th

SUBMITTER: Wang X 

PROVIDER: S-EPMC7918358 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature