Assessment of In-Situ Gelling Microemulsion Systems upon Temperature and Dilution Condition for Corneal Delivery of Bevacizumab.

ABSTRACT: Bevacizumab (BVZ), a recombinant humanized monoclonal antibody, has recently been proposed as a topical application in the treatment of anterior segment neovascularization; however, as there are some disadvantages in the administration of common eye-drops, ophthalmic topical drug delivery systems are under study to improve the precorneal residence time, reducing the frequency of administration. In this work, oil-in-water and water-in-oil BVZ-loaded microemulsions are developed, able to increase their viscosity, either by the formation of a liquid-crystalline structure upon aqueous dilution, thanks to the presence of Epikuron^® 200 and polysorbate 80, or by body-temperature-induced jellification for the presence of Pluronic^® F127 aqueous solution as an external phase. I

SUBMITTER: Peira E 

PROVIDER: S-EPMC7918509 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature