Zincbindpredict-Prediction of Zinc Binding Sites in Proteins.

ABSTRACT: Background: Zinc binding proteins make up a significant proportion of the proteomes of most organisms and, within those proteins, zinc performs rôles in catalysis and structure stabilisation. Identifying the ability to bind zinc in a novel protein can offer insights into its functions and the mechanism by which it carries out those functions. Computational means of doing so are faster than spectroscopic means, allowing for searching at much greater speeds and scales, and thereby guiding complimentary experimental approaches. Typically, computational models of zinc binding predict zinc binding for individual residues rather than as a single binding site, and typically do not distinguish between different classes of binding site-missing crucial properties indicative of zinc binding. Methods:

SUBMITTER: Ireland SM 

PROVIDER: S-EPMC7918553 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature