Receptor Tyrosine Kinase Signaling and Targeting in Glioblastoma Multiforme.

ABSTRACT: Glioblastoma multiforme (GBM) is amongst the deadliest of human cancers, with a median survival rate of just over one year following diagnosis. Characterized by rapid proliferation and diffuse infiltration into the brain, GBM is notoriously difficult to treat, with tumor cells showing limited response to existing therapies and eventually developing resistance to these interventions. As such, there is intense interest in better understanding the molecular alterations in GBM to guide the development of more efficient targeted therapies. GBM tumors can be classified into several molecular subtypes which have distinct genetic signatures, and they show aberrant activation of numerous signal transduction pathways, particularly those connected to receptor tyrosine kinases (RTKs) which control gli

SUBMITTER: Tilak M 

PROVIDER: S-EPMC7918566 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature