Neuroimaging Findings in Adolescents and Young Adults with Anorexia Nervosa: A Systematic Review.

ABSTRACT: Anorexia nervosa (AN) is a serious, multifactorial mental disorder affecting predominantly young females. This systematic review examines neuroimaging findings in adolescents and young adults up to 24 years old, in order to explore alterations associated with disease pathophysiology. Eligible studies on structural and functional brain neuroimaging were sought systematically in PubMed, CENTRAL and EMBASE databases up to 5 October 2020. Thirty-three studies were included, investigating a total of 587 patients with a current diagnosis of AN and 663 healthy controls (HC). Global and regional grey matter (GM) volume reduction as well as white matter (WM) microstructure alterations were detected. The mainly affected regions were the prefrontal, parietal and temporal cortex, hippocampus, amygdala

SUBMITTER: Kappou K 

PROVIDER: S-EPMC7918703 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature