Microtubule Destabilizing Sulfonamides as an Alternative to Taxane-Based Chemotherapy.

ABSTRACT: Pan-Gyn cancers entail 1 in 5 cancer cases worldwide, breast cancer being the most commonly diagnosed and responsible for most cancer deaths in women. The high incidence and mortality of these malignancies, together with the handicaps of taxanes-first-line treatments-turn the development of alternative therapeutics into an urgency. Taxanes exhibit low water solubility that require formulations that involve side effects. These drugs are often associated with dose-limiting toxicities and with the appearance of multi-drug resistance (MDR). Here, we propose targeting tubulin with compounds directed to the colchicine site, as their smaller size offer pharmacokinetic advantages and make them less prone to MDR efflux. We have prepared 52 new Microtubule Destabilizing Sulfonamides (MDS) that mostl

SUBMITTER: Gonzalez M 

PROVIDER: S-EPMC7918738 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature