Automated Red Cell Exchange in the Management of Sickle Cell Disease.

ABSTRACT: Red cell transfusion represents one of the cornerstones of the chronic management of sickle cell disease, as well as its acute complications. Automated red cell exchange can rapidly lower the number of circulating sickle erythrocytes, without causing iron overload. Here, we describe our experience, having offered this intervention since 2011. A transient reduction in the platelet count by 61% was observed after the procedure. This was not associated with any haemorrhagic complications. Despite exposure to large volumes of blood, the alloimmunisation rate was only 0.027/100 units of red cells. The absence of any iron loading was confirmed by serial Ferriscans, performed over a number of years. However, patients with advanced chronic kidney disease showed evidence of iron loading due to redu

SUBMITTER: Tsitsikas DA 

PROVIDER: S-EPMC7918980 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature