Safety and effectiveness concerns of lopinavir/ritonavir in COVID-19 affected patients: a retrospective series.

ABSTRACT:

Context

Originally developed for treatment of human immunodeficiency virus (HIV), the antiviral combination lopinavir/ritonavir (LPV/r) is being repurposed for treating the novel coronavirus disease (COVID-19) despite minimal experience in this markedly different population and an in-vitro derived EC50 against SARS-CoV-2 several hundred-fold greater than for HIV. We present a case series including a case of severe hyponatremia and a 32-fold overdose raising safety and effectiveness concerns in COVID-19 patients.

Methods

We measured LPV trough concentrations in 12 patients and reviewed their clinical charts for side effects known to occur in HIV patients.

Findings

Compared to established LPV trough concentrations in HIV patients, concentrations in COVID-19 patients wer

SUBMITTER: Lepage MA 

PROVIDER: S-EPMC7919102 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature