Tumor-educated platelet SNORD55 as a potential biomarker for the early diagnosis of non-small cell lung cancer.

ABSTRACT:

Background

Despite the emerging insights into many snoRNAs (small nucleolar RNAs) which are detectable in body fluids and serve as noninvasive biomarkers, few studies have previously discussed the role of snoRNAs in tumor-educated platelets (TEPs). Herein, we systematically estimated dysregulation of snoRNAs in non-small cell lung cancer (NSCLC) and clarified the biomarker potential of SNORD55 in platelets.

Methods

We compared expression of snoRNAs between NSCLC and normal tissues using SNORic datasets. Platelets were isolated from plasma using low-speed centrifugation and subjected to quantitative polymerase chain reaction (qPCR) for SNORD55 detection.

Results

SNORD55 was significantly decreased in TEPs from NSCLC patients especially in early-stage patients compared

SUBMITTER: Dong X 

PROVIDER: S-EPMC7919130 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature