Noninvasive Ventilation Use Is Associated with Better Survival in Amyotrophic Lateral Sclerosis.

ABSTRACT: Rationale: Noninvasive ventilation (NIV) is standard of care in amyotrophic lateral sclerosis (ALS), yet few data exist regarding its benefits.Objectives: We sought to identify whether the use of NIV was associated with survival in ALS.Methods: This was a single-center retrospective cohort study of 452 patients with ALS seen between 2006 and 2015. We matched one or more NIV subjects (prescribed NIV) to non-NIV subjects (never prescribed NIV) without replacement. The outcome was time from NIV prescription date (NIV subjects) or matched date (non-NIV subjects) until death. We performed a multivariable Cox proportional hazards model with NIV hourly usage as a time-varying covariate and stratified by matched groups.Results: After creating 180 matched groups and adju

SUBMITTER: Ackrivo J 

PROVIDER: S-EPMC7919153 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature