The Impact of Antifungal Prophylaxis in Lung Transplant Recipients.

ABSTRACT: Rationale: Many lung transplant centers prescribe antifungal medications after transplantation to prevent invasive fungal infections (IFIs); however, the effectiveness of antifungal prophylaxis at reducing the risk of all-cause mortality or IFI has not been established.Objectives: We aimed to evaluate the effect of antifungal prophylaxis on all-cause mortality and IFI in lung transplant patients.Methods: Using administrative claims data, we identified adult patients who underwent lung transplantation between January 1, 2005, and December 31, 2018. Propensity score analysis using inverse probability treatment-weighting approach was used to balance the differences in baseline characteristics between those receiving antifungal prophylaxis and those not receiving antifunga

SUBMITTER: Pennington KM 

PROVIDER: S-EPMC7919156 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature