Multiomics landscape of synovial fibroblasts in rheumatoid arthritis.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is an autoimmune disease characterized by tumor-like hyperplasia and inflammation of the synovium, which causes synovial cell invasion into the bone and cartilage. In RA pathogenesis, various molecules in effector cells (i.e., immune cells and mesenchymal cells) are dysregulated by genetic and environmental factors. Synovial fibroblasts (SFs), the most abundant resident mesenchymal cells in the synovium, are the major local effectors of the destructive joint inflammation and exert their effects through the pathogenic production of molecules such as interleukin-6.

Main body

To date, more than 100 RA susceptibility loci have been identified in genome-wide association studies (GWASs), and finding novel therapeutic targets utilizing genome an

SUBMITTER: Tsuchiya H 

PROVIDER: S-EPMC7919303 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature