UKCTOCS update: applying insights of delayed effects in cancer screening trials to the long-term follow-up mortality analysis.

ABSTRACT:

Background

During trials that span decades, new evidence including progress in statistical methodology, may require revision of original assumptions. An example is the continued use of a constant-effect approach to analyse the mortality reduction which is often delayed in cancer-screening trials. The latter led us to re-examine our approach for the upcoming primary mortality analysis (2020) of long-term follow-up of the United Kingdom Collaborative Trial of Ovarian Cancer Screening (LTFU UKCTOCS), having initially (2014) used the proportional hazards (PH) Cox model.

Methods

We wrote to 12 experts in statistics/epidemiology/screening trials, setting out current evidence, the importance of pre-specification, our previous mortality analysis (2014) and three possible choices for

SUBMITTER: Burnell M 

PROVIDER: S-EPMC7919310 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature