TMEM52B suppression promotes cancer cell survival and invasion through modulating E-cadherin stability and EGFR activity.

ABSTRACT:

Background

TMEM52B is a novel gene broadly expressed in a variety of normal human tissues. However, the biological function of TMEM52B expression in cancer is largely unknown.

Methods

The effects of TMEM52B on tumor growth and metastasis were investigated in vitro and in vivo, and the underlying biological and molecular mechanisms involved in this process were evaluated. Clinical datasets from KmPlotter and The Cancer Genome Atlas (TCGA) were analyzed in relation to TMEM52B expression and function.

Results

Suppression of TMEM52B in colon cancer cells promoted cancer cell epithelial-mesenchymal transition (EMT), invasion, and survival in vitro. Similarly, in vivo studies showed increased tumor growth and circulating tumor cell survival (early metastasis). ERK1/2, JNK,

SUBMITTER: Lee Y 

PROVIDER: S-EPMC7919321 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature