Vendor-specific microbiome controls both acute and chronic murine lung allograft rejection by altering CD4⁺ Foxp3⁺ regulatory T cell levels.

ABSTRACT: Despite standardized postoperative care, some lung transplant patients suffer multiple episodes of acute and chronic rejection while others avoid graft problems for reasons that are poorly understood. Using an established model of C57BL/10 to C57BL/6 minor antigen mismatched single lung transplantation, we now demonstrate that the recipient microbiota contributes to variability in the alloimmune response. Specifically, mice from the Envigo facility in Frederick, Maryland contain nearly double the number of CD4⁺ Foxp3⁺ regulatory T cells (T_regs ) than mice from the Jackson facility in Bar Harbor, Maine or the Envigo facility in Indianapolis, Indiana (18 vs 9 vs 7%). Lung graft recipients from the Maryland facility thus do not develop acute or chronic rejecti

SUBMITTER: Guo Y 

PROVIDER: S-EPMC7919421 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature