Abundantly expressed class of noncoding RNAs conserved through the multicellular evolution of dictyostelid social amoebas.

ABSTRACT: Aggregative multicellularity has evolved multiple times in diverse groups of eukaryotes, exemplified by the well-studied development of dictyostelid social amoebas, for example, Dictyostelium discoideum However, it is still poorly understood why multicellularity emerged in these amoebas while the majority of other members of Amoebozoa are unicellular. Previously, a novel type of noncoding RNA, Class I RNAs, was identified in D. discoideum and shown to be important for normal multicellular development. Here, we investigated Class I RNA evolution and its connection to multicellular development. We identified a large number of new Class I RNA genes by constructing a covariance model combined with a scoring system based on conserved upstream sequences. Multiple genes were predict

SUBMITTER: Kjellin J 

PROVIDER: S-EPMC7919456 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature